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Biotech goal: sweet-smelling blue roses

At Vanderbilt University School of Medicine, scientists studying how drugs metabolize in the liver stumbled across a human protein that may hold the key to creating the world's first-known blue rose.

Elizabeth Gillam, working in the lab of biochemist F. Peter Guengerich, amazed her boss one day with a flask full of bacteria that she turned blue with an enzyme taken from a patient's liver. They're now trying to insert into roses the human gene that produces that blue enzyme.

"I would have called you crazy five years ago if you told me I would be pursuing a blue rose," said Guengerich, who spends most of his time researching disease-fighting drugs. "It's not something we set out to do."

Guengerich marvels that so many gardening enthusiasts lust after the blue rose, the pursuit of which has reached near-mythical proportions.

"For some reason this is the holy grail for this type of work," Guengerich said. "We could try to create blue cotton, blue anything really."

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