integrins are seriously hard to target. There are a dozen or more cell adhesion thingies on blood vessels, its how immune cells traffic, among other things. you can name beta 1 integrin CD29 as the culprit, destroy it, and still...
oh here it is "there are at least 10 β1 integrin heterodimers which serve as variably promiscuous adhesive receptors to diverse ligands such as the collagens and laminins. Nonetheless our data suggest that antagonism of the β1 integrin subunit alone might be useful in therapeutic strategies for brain metastases."
orly? does it now? I don't see you antagonizing the son of a bitch. Who is? I must bring paper to work.... can't discuss more.. :>
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(no subject)
Date: 2009-06-16 04:50 am (UTC)is gonna be a bitch to counteract.
integrins are seriously hard to target. There are a dozen or more cell adhesion thingies on blood vessels, its how immune cells traffic, among other things. you can name beta 1 integrin CD29 as the culprit, destroy it, and still...
oh here it is
"there are at least 10 β1 integrin heterodimers which serve as variably promiscuous adhesive receptors to diverse ligands such as the collagens and laminins. Nonetheless our data suggest that antagonism of the β1 integrin subunit alone might be useful in therapeutic strategies for brain metastases."
orly? does it now? I don't see you antagonizing the son of a bitch. Who is? I must bring paper to work.... can't discuss more.. :>
(no subject)
Date: 2009-06-16 04:53 am (UTC)