damn it! now I can't remember if 5-HT2A receptors are ion gates or G-protein coupled receptors.
now I have to look it up.
genetic, electrophysiologic and cell signalling changes, eh? Now I need a subscription to Neuron to find out what those changes are.
obtw, I once saw a seminar about learning in rats, they'd discovered changes in HDAC expression levels in the...crap. my memory is so shot! hypothalamus? HDAC is histone deacetlyase; and histones are what DNA is wrapped around, acetylation and methylation state of histones is a very important mechanism of transcription regulation. when rats learn something, there are changes in the transcriptome of the ...hypothalamus? when short term memories are created. He had no gene expression data, just some protein data on HDAC levels. lessie...methylyation silences, acetylation opens DNA; deacetylation also silences? I will be looking this up now.
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(no subject)
Date: 2007-02-01 08:10 pm (UTC)now I have to look it up.
genetic, electrophysiologic and cell signalling changes, eh? Now I need a subscription to Neuron to find out what those changes are.
obtw, I once saw a seminar about learning in rats, they'd discovered changes in HDAC expression levels in the...crap. my memory is so shot! hypothalamus? HDAC is histone deacetlyase; and histones are what DNA is wrapped around, acetylation and methylation state of histones is a very important mechanism of transcription regulation. when rats learn something, there are changes in the transcriptome of the ...hypothalamus? when short term memories are created. He had no gene expression data, just some protein data on HDAC levels. lessie...methylyation silences, acetylation opens DNA; deacetylation also silences?
I will be looking this up now.
(no subject)
Date: 2007-02-01 08:20 pm (UTC)in most cases acetylation enhances transcription.
5-HT2A is a g-coupled protein receptor.
in practical terms, that means it do ANYTHING depending on the context, and probably does lots of things.
If you google 5-HT2A, theres a study on hallucinogens and some very technical stuff on where exactly the weirdness is.